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Author Science/Medical Day (JdaSilva?)
adiohead
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Registered: 28th Sep 01
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   23rd Sep 12 at 10:21   View User's Profile U2U Member Reply With Quote

Hi

Is anyone on here able to help with my ignorance.

What is the difference between Dextrothyroxine (D-thyroxine):



and Levothyroxine (L-thyroxine):



I know as much about them as wiki says, but what I want to know is if there is a major difference between the two or will both work in a similar way if given to a patient?

Hope someone knows about this stuff


[Edited on 23-09-2012 by adiohead]
adiohead
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Registered: 28th Sep 01
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23rd Sep 12 at 10:26   View User's Profile U2U Member Reply With Quote

I found this out:

The prefixes "(+)-", "(–)-", "d-", "l-", "D-", and "L-"
A dextrorotary compound is often prefixed "(+)-" or "d-". Likewise, a levorotary compound is often prefixed "(–)-" or "l-". These "d-" and "l-" prefixes should not be confused with the "D-" and "L-" prefixes based on the actual configuration of each enantiomer, with the version synthesized from naturally occurring (+)-glyceraldehyde being considered the D- form. For example, nine of the nineteen L-amino acids commonly found in proteins are dextrorotatory (at a wavelength of 589 nm), and D-fructose is also referred to as levulose because it is levorotatory
Colin
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Registered: 4th Apr 02
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23rd Sep 12 at 10:37   View User's Profile U2U Member Reply With Quote

Double bonds are in different places!
adiohead
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Registered: 28th Sep 01
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23rd Sep 12 at 11:18   View User's Profile U2U Member Reply With Quote

Yeah that and the H is solid in one and not in the other, but what does it mean?
tom130691
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Registered: 13th Sep 08
Location: Daventry
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23rd Sep 12 at 11:27   View Garage View User's Profile U2U Member Reply With Quote

next the H one cone is solid one isnt
LeeM
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Registered: 26th Sep 05
Location: Liverpool
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23rd Sep 12 at 15:04   View User's Profile U2U Member Reply With Quote

quote:
Originally posted by tom130691
next the H one cone is solid one isnt


its not a spot the difference
adiohead
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Registered: 28th Sep 01
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24th Sep 12 at 09:06   View User's Profile U2U Member Reply With Quote

Bump.

Anyone with medical knowledge?
Welsh Dan
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Registered: 23rd Mar 00
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24th Sep 12 at 09:39   View User's Profile U2U Member Reply With Quote

Levothyroxine is used for the treatment of under active thyroid glands. I presume D is the opposite. Only based on the fact that I take Levo and have never heard of the other.

[Edited on 24-09-2012 by Welsh Dan]
John
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Registered: 30th Jun 03
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24th Sep 12 at 09:55   View User's Profile U2U Member Reply With Quote

Presuming D is the opposite because you've never heard of it

http://jcem.endojournals.org/content/49/1/1.short That's a paper on it, can't find it for free though.

From the abstract it would look like they both perform the same function.

 
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